The fourth stage is the largest in length of this year's event (196.53 km). The riders will start from Spercheiada at the Prefecture of Fthiotida, and head east until the intermediate sprint in Lamia. From there they will change direction, heading south, to enter Viotia, passing the two largest cities, Livadeia and Thebes. After Thebes they will once again change direction, heading towards the northeast to Chalkida, with the finish line placed on the city's old bridge, next to the Euripus Strait. A stage, in which a classic battle between the breakaway group and the sprinters is expected to unfold.

km 0: Starting Point / Spercheiada
km 27,9: Intermediate Sprint 1 / Lamia
km 49,8: KoM 1 (Cat. 2) / Chani Karanasiou (Eleftherochori)
km 117,2: Intermediate Sprint 2 / Livadeia
km 161,9: Intermediate Sprint 3 / Thiva
km 187,6: KoM 2 (Cat. 3) / Profitis Ilias junction
km 196,53: Finish Line / Chalkida